That headline is misleading. There aren’t “eight pills everyone should never take,” but there are medications that can harm the kidneys in some people, especially at high doses, with long-term use, or in people who already have kidney disease.
Some examples include:
- Nonsteroidal anti-inflammatory drugs (NSAIDs) such as Ibuprofen and Naproxen
- Can reduce blood flow to the kidneys.
- Risk is higher in older adults, people with dehydration, heart failure, or kidney disease.
- Certain antibiotics
- Some antibiotics can affect kidney function, particularly at high doses or in susceptible individuals.
- Certain diuretics (“water pills”)
- Can contribute to dehydration and electrolyte imbalances if not monitored properly.
- Some blood pressure medications
- Drugs such as ACE inhibitors and ARBs can affect kidney function, although they are also commonly used to protect kidneys in many patients. Monitoring is important.
- Certain antiviral medications
- Some require dose adjustments in people with reduced kidney function.
- Some chemotherapy drugs
- Certain cancer treatments are known to have kidney-related side effects.
- Certain lithium-containing medications
- Long-term use can affect kidney function in some people.
- Some herbal supplements
- Certain herbal products have been linked to kidney injury, especially when ingredients are unclear.
Important reality check
Many of these medications are safe and beneficial when:
- Prescribed appropriately
- Taken at the correct dose
- Monitored when necessary
The danger comes from factors such as:
- Taking more than recommended
- Combining medications in risky ways
- Using them despite significant kidney disease
- Becoming dehydrated while taking them
Warning signs of possible kidney problems
Seek medical advice if you develop:
- Reduced urine output
- Swelling of the legs, ankles, or face
- Unexplained fatigue
- Nausea or vomiting
- Shortness of breath
- Sudden changes in blood pressure
Bottom line
