The headline is too broad. Many medications can affect the kidneys in some people or under certain conditions, but that doesn’t mean no one should ever take them. Often, the benefits outweigh the risks when they’re used correctly and monitored.
Some medications that can increase the risk of kidney problems include:
- Ibuprofen and other NSAIDs (such as Naproxen)
- Can reduce blood flow to the kidneys, especially in people with chronic kidney disease, dehydration, heart failure, or older age.
- Diclofenac
- Another NSAID with similar kidney risks.
- Certain antibiotics, such as Gentamicin
- Can be toxic to the kidneys, particularly with prolonged use or high doses.
- Some antiviral medications
- Certain drugs require dose adjustments in people with reduced kidney function.
- Certain chemotherapy drugs
- Some cancer treatments can affect kidney function and require close monitoring.
- Lithium
- Long-term use can affect kidney function in some people, so regular blood tests are recommended.
- Some diuretics (“water pills”)
- Can contribute to dehydration or electrolyte imbalances, which may affect the kidneys if not managed properly.
- High doses or prolonged use of proton pump inhibitors, such as Omeprazole
- Rarely, these medications have been linked to kidney inflammation, although the absolute risk is low.
How to reduce your risk
- Take medications exactly as prescribed.
- Stay well hydrated unless your healthcare professional has advised you to restrict fluids.
- Tell your healthcare provider if you have Chronic kidney disease, diabetes, heart failure, or are over 65, as these factors may increase the risk of medication-related kidney problems.
- Have kidney function monitored when taking medications known to affect the kidneys.
Don’t stop medications on your own
If you’re taking any of the medications above, don’t stop them without talking to your healthcare provider. Many are important treatments, and if they pose a kidney risk, your clinician can often reduce that risk by adjusting the dose, monitoring kidney function, or choosing an alternative when appropriate.
